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the space involving the oxygen atom of Thr164 of Aph1 as well as oxygen atom of Tyr466 of PS1 is predicted to be three.5 Å, suggesting that a hydrogen bond (H...O distance, somewhere around one.8 Å) is fashioned in these facet chains (Figure 7b). The T164A mutation may perhaps eradicate the hydrogen bond with PS1 Y466, leading to adaptable motion on the carboxy terminus of PS1. We propose that Aph1 mutations regulate protease exercise by way of conformational variations in PS1.
Firas Hassan sudah dipenjara pada Oktober, dan ditahan di bawah “penahanan administratif”, sebuah tindakan yang memungkinkan tersangka – meskipun banyak diterapkan pada warga Palestina – dapat ditahan, tanpa batas waktu, tanpa dakwaan.
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